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Association of Outcome with Early Stroke Treatment:Pooled Analysis of ATLANTIS, ECASS, and NINDS rt-PA Stroke Trials Lancet 363:768-774, The ATLANTIS,ECASS,and NINDS rt-PA Study Group, 2004 See this aricle in Pubmed Article Abstract The sooner that rt-PA is given to stroke patients, the greater the benefit, especially if started within 90 min. Our results suggest a potential benefit beyond 3 h, but this potential might come with some risks.

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